Scott & White Digestive Disease Research Center, Department of Medicine, Division Gastroenterology, Texas A&M Health Science Center, Temple, Texas, USA.
Curr Opin Gastroenterol. 2010 May;26(3):246-50. doi: 10.1097/MOG.0b013e3283369d19.
Recent studies have brought to light that angiogenesis and the expression of pro-angiogenic factors such as vascular endothelial growth factors (VEGFs) participate in the pathogenesis of biliary tract diseases. This review summarizes recent progress that has been accomplished in the field, which expands our understanding of the relationship between vascular growth and the biliary tract, particularly the molecular mechanisms that underlie the pathogenesis of biliary tract diseases.
Angiogenesis and the expression of vascular factors play a key role in the pathogenesis of primary biliary cirrhosis, cholangiocarcinoma, liver cysts, and in the progression of biliary fibrosis in animal models. Inhibition of angiogenesis limits fibrosis in animal models, whereas the bile acid, taurocholate, has protective effects in animal models of bile duct and peribiliary vascular plexus damage.
A widening body of information indicates that the expression of pro-angiogenic factors such as VEGFs and angiogenesis play an important role in a variety of biliary tract diseases. Further characterization of the link between angiogenesis and vascular growth factor expression will help in elucidating the mechanisms regulating the pathogenesis of biliary tract diseases and in devising new treatment approaches for these devastating diseases.
最近的研究表明，血管生成和促血管生成因子（如血管内皮生长因子 [VEGFs]）的表达参与了胆道疾病的发病机制。本综述总结了该领域最近取得的进展，这些进展扩展了我们对血管生长与胆道之间关系的理解，特别是对胆道疾病发病机制的分子机制的理解。
血管生成和血管因子的表达在原发性胆汁性肝硬化、胆管癌、肝囊肿以及动物模型中的胆道纤维化进展中起着关键作用。在动物模型中，抑制血管生成可限制纤维化，而胆酸牛磺胆酸盐在胆管和胆周血管丛损伤的动物模型中具有保护作用。
越来越多的信息表明，促血管生成因子如 VEGFs 的表达和血管生成在多种胆道疾病中起着重要作用。进一步阐明血管生成与血管生长因子表达之间的联系将有助于阐明调节胆道疾病发病机制的机制，并为这些破坏性疾病设计新的治疗方法。
