常见的 2q37.3、8q24.21、15q21.3 和 16q24.1 变异与慢性淋巴细胞白血病风险相关。
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.
机构信息
Institute of Cancer Research, Sutton, Surrey, UK.
出版信息
Nat Genet. 2010 Feb;42(2):132-6. doi: 10.1038/ng.510. Epub 2010 Jan 10.
To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
为了鉴定慢性淋巴细胞白血病（CLL）的新风险变异，我们对 299983 个标签 SNP 进行了全基因组关联研究，在另外四个系列中进行了验证，总共有 2503 例病例和 5789 例对照。我们在 2q37.3（rs757978，FARP2；优势比（OR）=1.39；P=2.11×10(-9)）、8q24.21（rs2456449；OR=1.26；P=7.84×10(-10)）、15q21.3（rs7169431；OR=1.36；P=4.74×10(-7)）和 16q24.1（rs305061；OR=1.22；P=3.60×10(-7)）发现了四个新的 CLL 风险位点。我们还在 15q25.2（rs783540，CPEB1；OR=1.18；P=3.67×10(-6)）和 18q21.1（rs1036935；OR=1.22；P=2.28×10(-6)）发现了风险位点的证据。这些数据为这种 B 细胞血液恶性肿瘤的遗传易感性提供了进一步的证据。
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