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人体皮肤中维生素 D3 前体的 UV 诱导生成作用的光谱是否正确?

Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

机构信息

Biomedical Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.

出版信息

Photochem Photobiol Sci. 2010 Jan;9(1):11-7. doi: 10.1039/b9pp00012g. Epub 2009 Oct 19.

Abstract

The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D(3) in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.

摘要

1982 年发表了普遍认可的人类皮肤中 7-脱氢胆固醇转化为前维生素 D(3)的紫外线诱导作用光谱,表明在大约 297nm 处有最大值,在 315nm 以上基本上没有产生。这项工作是维生素 D 研究的一个里程碑,但应该认识到原始数据的局限性。近年来出现了各种发现,这些发现对作用光谱的准确性及其在有效紫外线剂量计算中的光谱加权应用提出了质疑。总之,建议构建一个全新的计算模型来预测前维生素 D 水平。

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