The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales 2145, Australia.
Int J Eat Disord. 2011 Jan;44(1):65-75. doi: 10.1002/eat.20777.
To examine resting awake EEG in adolescent AN participants before and after refeeding to determine if EEG abnormalities in Anorexia Nervosa (AN) are reversible.
In 37 adolescent first admission AN patients and 45 healthy controls, EEG was recorded during short duration "eyes open" and "eyes closed" awake resting conditions. Repeat testing occurred in 28 AN participants after refeeding and subsequent weight gain.
In "eyes open," underweight AN participants exhibit reduced relative alpha power and increased beta power in frontal brain regions. A significant increase in alpha, and decrease in beta and delta power was observed within participants after refeeding. In "eyes closed", underweight AN participants had elevated theta in parietal-occipital regions which remained after refeeding.
EEG abnormalities (reduced alpha/increased beta power) in AN normalizes with refeeding, while increased theta power persists in parietal-occipital regions in an eyes closed context.
通过观察厌食症（AN）青少年患者在接受再喂养前后的清醒静息脑电图（EEG），以确定 AN 患者的脑电图异常是否可逆。
在 37 名首次入院的青少年 AN 患者和 45 名健康对照者中，在短时间的“睁眼”和“闭眼”清醒静息状态下记录 EEG。在再喂养和随后的体重增加后，对 28 名 AN 患者进行了重复测试。
在“睁眼”状态下，体重不足的 AN 患者在前额脑区表现出相对阿尔法功率降低和贝塔功率增加。再喂养后，参与者的阿尔法功率显著增加，贝塔和德尔塔功率显著降低。在“闭眼”状态下，体重不足的 AN 患者在顶枕部区域出现升高的θ波，这种情况在再喂养后仍然存在。
AN 患者的脑电图异常（阿尔法功率降低/贝塔功率增加）在再喂养后恢复正常，而在闭眼状态下顶枕部区域的θ波功率增加持续存在。
