Al-Zaher Nabil, Obeid Amani, Al-Salam Suhail, Al-Kayyali Bassam Sulaiman
Department of Otolaryngology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Hematol Oncol Stem Cell Ther. 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0.
Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men. Previous radiation exposure and familial predisposition are some of the risk factors for ACC. A slowly enlarging mass lesion in the tail of the parotid gland is the most frequent presentation. The diagnosis is usually confirmed with a fine needle aspiration biopsy, and surgical excision is the main treatment of this malignant neoplasm. Other treatment modalities such as radiotherapy may be indicated in some cases. ACC has a significant tendency to recur, to produce metastases (cervical lymph nodes and lungs), and may have an aggressive evolution. Therefore, long-term follow-up is mandatory after treatment.
腺泡细胞癌（ACC）是一种低度恶性的涎腺肿瘤，约占原发性涎腺恶性肿瘤的17%。在头颈部区域，腮腺是主要的起源部位，女性通常比男性更易被诊断出。既往有放疗史和家族易感性是ACC的一些危险因素。腮腺尾部缓慢增大的肿块病变是最常见的表现。通常通过细针穿刺活检确诊，手术切除是这种恶性肿瘤的主要治疗方法。在某些情况下可能需要其他治疗方式，如放疗。ACC有显著的复发倾向、发生转移（颈部淋巴结和肺部）的倾向，并且可能进展迅速。因此，治疗后必须进行长期随访。
