Munteanu Maria Cristina, Mărgăritescu Cl, Cionca Lucia, Niţulescu N C, Dăguci Luminiţa, Ciucă E M
Department of Pathology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Rom J Morphol Embryol. 2012;53(2):313-20.
Acinic cell carcinoma (ACC) is the third most common epithelial malignancy of the salivary glands in adults, with a low-grade malignancy that mainly occurs in the parotid gland and at a relatively younger age than other salivary gland tumors. We made a retrospective study on our acinic cell carcinoma casuistry aiming their clinico-pathological characterization and comparison with literature data. From 2000 through 2011 in our hospital were diagnosed only 12 cases of ACC. The clinico-epidemiological study revealed prevalence of these tumors in women, in the fourth decade of life and especially occurring in the parotid gland. The most common morphologic pattern of these tumors was a mixture of two or more variants with the solid/lobular and microcystic patterns more frequent associated. In 75% of investigated cases, the pTNM stage was I/II, with no cases of perineural or vascular invasion, but with lymph node dissemination presented in only three cases. Summing all these clinicopathological features, we conclude that for our casuistry the biological behavior of these tumors has been of low-grade malignancy.
腺泡细胞癌（ACC）是成人唾液腺中第三常见的上皮性恶性肿瘤，恶性程度较低，主要发生于腮腺，发病年龄相对低于其他唾液腺肿瘤。我们对我院收治的腺泡细胞癌病例进行了回顾性研究，旨在对其临床病理特征进行分析并与文献数据进行比较。2000年至2011年期间，我院仅诊断出12例ACC。临床流行病学研究显示，这些肿瘤在女性中更为常见，发病年龄多在40岁左右，且尤其好发于腮腺。这些肿瘤最常见的形态学模式是两种或更多种变体的混合，其中实性/小叶状和微囊状模式更为常见。在75%的研究病例中，pTNM分期为I/II期，无神经周围或血管侵犯病例，但仅有3例出现淋巴结转移。综合所有这些临床病理特征，我们得出结论，就我们的病例而言，这些肿瘤的生物学行为为低级别恶性。
