Human Sciences Research Council, Pretoria, South Africa.
Acta Paediatr. 2010 Apr;99(4):590-6. doi: 10.1111/j.1651-2227.2009.01670.x. Epub 2010 Jan 8.
The aim of this study was to investigate factors determining HIV viral testing of infants in the context of Prevention of Mother-to-Child Transmission of HIV (PMTCT).
Post-delivery HIV infected mothers 18 years and above with babies aged 3-6 months were interviewed on HIV viral testing of infants and factors associated with it.
Among 311 HIV infected women 61.7% had their infant tested for HIV between 4 and 8 weeks. Bivariate analyses found that older age of the mothers, lower depression scores, higher PMTCT knowledge, low PMTCT risk behaviour (maternal and infant nevirapine adherence, health facility delivery and exclusive formula feeding), HIV status disclosure and attending a support group were associated with PCR test participation. In multivariate analyses higher PMTCT knowledge, infant nevirapine adherence, and not exclusive breast feeding were associated with polymerase chain reaction test participation.
Various determinants of acceptance of participation in HIV viral testing of infants in the context of PMTCT were identified that can guide infant testing and diagnosis counselling and support services of PMTCT programmes.
本研究旨在探讨预防母婴传播 HIV（PMTCT）背景下婴儿 HIV 病毒检测的决定因素。
对产后 18 岁及以上、婴儿年龄为 3-6 个月的 HIV 感染母亲进行婴儿 HIV 病毒检测及其相关因素的访谈。
在 311 名 HIV 感染妇女中，61.7%的婴儿在 4-8 周内接受了 HIV 检测。单因素分析发现，母亲年龄较大、抑郁评分较低、PMTCT 知识水平较高、PMTCT 风险行为较低（母婴奈韦拉平依从性、医疗机构分娩和纯配方喂养）、HIV 状态披露和参加支持小组与 PCR 检测参与有关。多因素分析显示，较高的 PMTCT 知识、婴儿奈韦拉平的依从性和非纯母乳喂养与聚合酶链反应检测参与有关。
确定了 PMTCT 背景下接受婴儿 HIV 病毒检测的各种决定因素，这些因素可以指导婴儿检测和诊断咨询以及 PMTCT 项目的支持服务。
