FANCM：范可尼贫血症和布卢姆综合征复合物的着陆平台。
FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes.
机构信息
Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
出版信息
Mol Cell. 2009 Dec 25;36(6):916-7. doi: 10.1016/j.molcel.2009.12.007.
Abstract
In this issue of Molecular Cell, Deans and West (2009) reveal the molecular basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FANCM as the anchor for both FA and Bloom's complexes at the site of the DNA interstrand crosslink.
摘要
在本期《分子细胞》中，Deans 和 West（2009）揭示了范可尼贫血症（FA）和布卢姆综合征之间表型相似的分子基础，确定 FANCM 是 FA 和布卢姆复合物在 DNA 链间交联部位的连接点。
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本文引用的文献
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2
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.范可尼贫血通路促进复制依赖性 DNA 链间交联修复。
Science. 2009 Dec 18;326(5960):1698-701. doi: 10.1126/science.1182372. Epub 2009 Nov 12.
3
How the fanconi anemia pathway guards the genome.范可尼贫血通路如何保护基因组。
Annu Rev Genet. 2009;43:223-49. doi: 10.1146/annurev-genet-102108-134222.
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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.复制应激在有丝分裂过程中诱导脆弱位点处的姐妹染色单体桥接。
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