骨科患者用金黄色葡萄球菌疫苗：经济模型与分析。
Staphylococcus aureus vaccine for orthopedic patients: an economic model and analysis.
机构信息
Section of Decision Sciences and Clinical Systems Modeling, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Vaccine. 2010 Mar 11;28(12):2465-71. doi: 10.1016/j.vaccine.2009.12.075. Epub 2010 Jan 9.
Abstract
To evaluate the potential economic value of a Staphylococcus aureus vaccine for pre-operative orthopedic surgery patients, we developed an economic computer simulation model. At MRSA colonization rates as low as 1%, a $50 vaccine was cost-effective [<or=$50,000 per quality-adjusted life year (QALY) saved] at vaccine efficacy >or=30%, and a $100 vaccine at vaccine efficacy >or=70%. High MRSA prevalence (>or=25%) could justify a vaccine price as high as $1000. Our results suggest that a S. aureus vaccine for the pre-operative orthopedic population would be very cost-effective over a wide range of MRSA prevalence and vaccine efficacies and costs.
摘要
为了评估一种金黄色葡萄球菌疫苗在接受骨科手术的术前患者中的潜在经济价值，我们开发了一个经济计算机模拟模型。在 MRSA 定植率低至 1%的情况下，如果疫苗的有效性大于等于 30%，那么每挽救一个质量调整生命年（QALY）的成本就低于 50 美元（<50,000 美元/QALY）；如果疫苗的有效性大于等于 70%，那么每挽救一个质量调整生命年的成本就低于 100 美元。MRSA 高流行率（>or=25%）可能会使疫苗价格高达 1000 美元。我们的研究结果表明，在广泛的 MRSA 流行率和疫苗有效性及成本范围内，用于术前骨科人群的金黄色葡萄球菌疫苗具有非常高的成本效益。
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