Di Cicco D, Antal S, Ammassari-Teule M
Istituto di Psicobiologia e Psicofarmacologia del CNR, Rome, Italy.
Teratology. 1991 Jan;43(1):61-70. doi: 10.1002/tera.1420430108.
The effects of prenatal exposure on gamma/neutron radiations (0.5 Gy at about the 18th day of fetal life) were studied in a hybrid strain of mice (DBA/Cne males x C57BL/Cne females). During ontogeny, measurements of sensorimotor reflexes revealed in prenatally irradiated mice 1) a delay in sensorial development, 2) deficits in tests involving body motor control, and 3) a reduction of both motility and locomotor activity scores. In adulthood, the behaviour of prenatally irradiated and control mice was examined in the open field test and in reactivity to novelty. Moreover, their learning performance was compared in several situations. The results show that, in the open field test, only rearings were more frequent in irradiated mice. In the presence of a novel object, significant sex x treatment interactions were observed since ambulation and leaning against the novel object increased in irradiated females but decreased in irradiated males. Finally, when submitted to different learning tasks, irradiated mice were impaired in the radial maze, but paradoxically exhibited higher avoidance scores than control mice, possibly because of their low pain thresholds. Taken together, these observations indicate that late prenatal gamma/neutron irradiation induces long lasting alterations at the sensorimotor level which, in turn, can influence learning abilities of adult mice.
在一种杂交品系小鼠（DBA/Cne雄性×C57BL/Cne雌性）中研究了产前暴露于γ/中子辐射（在胎儿生命约第18天给予0.5 Gy）的影响。在个体发育过程中，对感觉运动反射的测量显示，产前受辐照的小鼠：1）感觉发育延迟；2）在涉及身体运动控制的测试中存在缺陷；3）运动能力和自发活动得分均降低。成年后，在旷场试验和对新事物的反应性方面对产前受辐照小鼠和对照小鼠的行为进行了检查。此外，还在几种情况下比较了它们的学习表现。结果表明，在旷场试验中，仅受辐照小鼠的竖毛行为更为频繁。在有新物体存在时，观察到显著的性别×处理交互作用，因为受辐照雌性的走动和靠向新物体的行为增加，而受辐照雄性则减少。最后，当接受不同的学习任务时，受辐照小鼠在放射状迷宫中表现受损，但矛盾的是，其回避得分高于对照小鼠，这可能是因为它们的疼痛阈值较低。综上所述，这些观察结果表明，产前晚期γ/中子辐射在感觉运动水平上诱导了长期的改变，进而可能影响成年小鼠的学习能力。
