Effects of low level prenatal 60Co gamma-irradiation on postnatal growth and behavior in mice.

Pregnant Kun Ming strain mice were exposed to a total dose of 0, 0.1, 0.2, or 0.4 Gy from 60Co gamma-rays from the 13th to the 18th days of gestation. An overall delay of the appearance of two physiologic markers (pinna detachment, eye opening) and the age of acquisition of four reflexes (surface righting, air righting, auditory startle, visual placing) was observed in offspring exposed to 0.2 or 0.4 Gy in utero. Postnatal growth retardation, shortened length of hanging time, inhibited exploratory activity in the hole board test (decreased number of head-dipping), and hyperactivity in the open field test (shortened latency to leave the center area and increased number of squares entered) were also found among the offspring exposed to 0.2 Gy or more in utero. The results indicate that 0.1-0.2 Gy may represent a threshold range in mice for certain physiologic and behavioral effects resulting from continuous exposure to 60Co gamma-rays on the 13th-18th days of gestation.