对克氏锥虫血清阳性和恰加斯病临床形式的家族分析。
Familial analysis of seropositivity to Trypanosoma cruzi and of clinical forms of Chagas disease.
机构信息
Disciplina de Genética, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
出版信息
Am J Trop Med Hyg. 2010 Jan;82(1):45-8. doi: 10.4269/ajtmh.2010.08-0626.
A cross-sectional study was carried out in Agua Comprida, MG, Brazil, a region previously endemic to Chagas disease whose vectorial transmission was interrupted around 20 year ago. A total of 998 individuals were examined for anti-Trypanosoma cruzi antibodies. Seropositivity was observed in 255 subjects (25.5%), and 743 subjects were negative. Forty-one families with 5-80 individuals with similar environmental conditions were selected for familial analysis. In 15 families, seropositivity to T. cruzi was observed in > 50% of individuals. The segregation analysis confirmed family aggregation for the seropositivity to the T. cruzi. Heart commitment was the major clinical form observed, and in six families, > 50% of the individuals display cardiopathy that may be attributed to T. cruzi infection. Our results support the hypothesis that there is a family aggregation for the seropositivity but without the effect of one major gene.
巴西米纳斯吉拉斯州阿瓜普鲁达市开展了一项横断面研究，该地区曾是恰加斯病的流行区，20 年前已阻断其媒介传播。共检查了 998 人是否存在抗克氏锥虫抗体。255 人（25.5%）呈阳性，743 人呈阴性。选择 41 个有 5-80 名具有相似环境条件的个体的家族进行家族分析。在 15 个家族中，超过 50%的个体对克氏锥虫呈阳性。分离分析证实了克氏锥虫血清阳性的家族聚集性。心脏病变是主要的临床形式，在 6 个家族中，超过 50%的个体患有心脏病，可能与克氏锥虫感染有关。我们的结果支持了这样一种假设，即存在针对血清阳性的家族聚集性，但没有主要基因的影响。
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