非杀菌性抗生素达托霉素对实验性肺炎球菌性脑膜炎脑脊液炎症的抑制作用优于头孢曲松。
Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis.
机构信息
Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2010 Mar;54(3):1323-6. doi: 10.1128/AAC.00812-09. Epub 2010 Jan 11.
Abstract
Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.
摘要
抗生素诱导的细菌溶解会加剧细菌性脑膜炎的炎症和脑损伤。在这里，评估了非溶菌性抗生素达托霉素与头孢曲松在婴儿大鼠肺炎球菌性脑膜炎模型中的脑脊液（CSF）炎症的质量和时间动力学。达托霉素导致 CSF 中白细胞介素 1β（IL-1β）、IL-10、IL-18、单核细胞趋化蛋白 1（MCP-1）和巨噬细胞炎症蛋白 1α（MIP-1α）浓度降低（P < 0.05）。在实验性肺炎球菌性脑膜炎中，与头孢曲松治疗相比，达托霉素治疗导致更快的细菌清除、更低的 CSF 炎症和更少的脑损伤。
相似文献
1
Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis.
Antimicrob Agents Chemother. 2010 Mar;54(3):1323-6. doi: 10.1128/AAC.00812-09. Epub 2010 Jan 11.
2
Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis.
Antimicrob Agents Chemother. 2012 Aug;56(8):4289-95. doi: 10.1128/AAC.00674-12. Epub 2012 May 29.
3
Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis.
Antimicrob Agents Chemother. 2007 Jun;51(6):2173-8. doi: 10.1128/AAC.01014-06. Epub 2007 Mar 19.
4
Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
Antimicrob Agents Chemother. 2007 Jun;51(6):2249-52. doi: 10.1128/AAC.01000-06. Epub 2007 Mar 19.
5
Experimental study of cerebrospinal fluid tumor necrosis factor-alpha release in penicillin- and cephalosporin-resistant pneumococcal meningitis treated with different antibiotic schedules.
J Microbiol Immunol Infect. 2017 Aug;50(4):435-439. doi: 10.1016/j.jmii.2015.07.014. Epub 2015 Sep 9.
6
Protection of blood brain barrier integrity and modulation of inflammatory mediators during treatment of pneumococcal meningitis with daptomycin or ceftriaxone.
Curr Neurovasc Res. 2014;11(3):210-22. doi: 10.2174/1567202611666140520123424.
7
Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis.
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00220-19. Print 2019 Jul.
8
Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis.
J Neuroinflammation. 2018 Aug 21;15(1):233. doi: 10.1186/s12974-018-1272-8.
9
Experimental study of the efficacy of daptomycin for the treatment of cephalosporin-resistant pneumococcal meningitis.
J Antimicrob Chemother. 2014 Nov;69(11):3020-6. doi: 10.1093/jac/dku231. Epub 2014 Jun 23.
10
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.
J Neuroinflammation. 2019 Jul 27;16(1):156. doi: 10.1186/s12974-019-1549-6.
引用本文的文献
1
Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models.
Brain Commun. 2024 Apr 12;6(3):fcae131. doi: 10.1093/braincomms/fcae131. eCollection 2024.
2
Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study.
BMJ Open. 2023 Jul 25;13(7):e073032. doi: 10.1136/bmjopen-2023-073032.
3
Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes.
Antibiotics (Basel). 2023 Apr 27;12(5):822. doi: 10.3390/antibiotics12050822.
4
Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds.
Life (Basel). 2022 Jul 21;12(7):1096. doi: 10.3390/life12071096.
5
Mini-Review: Bioactivities of Bacterial Cell Envelopes in the Central Nervous System.
Front Cell Infect Microbiol. 2020 Oct 26;10:588378. doi: 10.3389/fcimb.2020.588378. eCollection 2020.
6
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis.
J Neuroinflammation. 2019 Jul 27;16(1):156. doi: 10.1186/s12974-019-1549-6.
7
Acute Bacterial Meningitis: Challenges to Better Antibiotic Therapy.
ACS Infect Dis. 2019 Dec 13;5(12):1987-1995. doi: 10.1021/acsinfecdis.9b00122. Epub 2019 Jul 3.
8
Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis.
Front Neurol. 2019 Jun 10;10:570. doi: 10.3389/fneur.2019.00570. eCollection 2019.
9
Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis.
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00220-19. Print 2019 Jul.
10
The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies.
Front Microbiol. 2019 Mar 25;10:576. doi: 10.3389/fmicb.2019.00576. eCollection 2019.
本文引用的文献
1
Short-term rifampicin pretreatment reduces inflammation and neuronal cell death in a rabbit model of bacterial meningitis.
Crit Care Med. 2009 Jul;37(7):2253-8. doi: 10.1097/CCM.0b013e3181a036c0.
2
Daptomycin in experimental murine pneumococcal meningitis.
BMC Infect Dis. 2009 Apr 30;9:50. doi: 10.1186/1471-2334-9-50.
3
Combination of daptomycin plus ceftriaxone is more active than vancomycin plus ceftriaxone in experimental meningitis after addition of dexamethasone.
Antimicrob Agents Chemother. 2009 Jul;53(7):3030-3. doi: 10.1128/AAC.00952-08. Epub 2009 Apr 13.
4
Daptomycin: mechanisms of action and resistance, and biosynthetic engineering.
Curr Opin Chem Biol. 2009 Apr;13(2):144-51. doi: 10.1016/j.cbpa.2009.02.031. Epub 2009 Mar 19.
5
Successful treatment of methicillin-resistant staphylococcus aureus meningitis with daptomycin.
Clin Infect Dis. 2008 Aug 15;47(4):588-90. doi: 10.1086/590257.
6
Essential role of choline for pneumococcal virulence in an experimental model of meningitis.
J Intern Med. 2008 Aug;264(2):143-54. doi: 10.1111/j.1365-2796.2008.01930.x. Epub 2008 Mar 5.
7
Daptomycin does not exert immunomodulatory effects in an experimental endotoxin model of human whole blood.
Pharmacology. 2008;81(1):57-62. doi: 10.1159/000108106. Epub 2007 Sep 11.
8
Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis.
Antimicrob Agents Chemother. 2007 Jun;51(6):2173-8. doi: 10.1128/AAC.01014-06. Epub 2007 Mar 19.
9
Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
Antimicrob Agents Chemother. 2007 Jun;51(6):2249-52. doi: 10.1128/AAC.01000-06. Epub 2007 Mar 19.
10
Corticosteroids for acute bacterial meningitis.
Cochrane Database Syst Rev. 2007 Jan 24(1):CD004405. doi: 10.1002/14651858.CD004405.pub2.
Zotero 插件