与头孢曲松相比，达托霉素在由耐青霉素肺炎球菌菌株引起的实验性脑膜炎中，通过脑脊液中[3H]胆碱释放量测定，在不裂解其细胞壁的情况下产生增强的杀菌活性。
Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
作者信息
Stucki A, Cottagnoud M, Winkelmann V, Schaffner T, Cottagnoud P
机构信息
Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2007 Jun;51(6):2249-52. doi: 10.1128/AAC.01000-06. Epub 2007 Mar 19.
Abstract
Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
摘要
达托霉素单药治疗优于头孢曲松单药治疗，在实验性肺炎球菌性脑膜炎中疗效显著，4至6小时后三只兔子的脑脊液（CSF）均除菌。使用达托霉素治疗时，脑脊液中仅可检测到极少量作为细胞壁溶解标志物的[(3)H]胆碱释放，4小时后峰值约为250 cpm/分钟，而头孢曲松治疗的兔子在4至6小时后的峰值约为2400 cpm/分钟。
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