Institute for Systems Biology, Seattle, WA 98103, USA.
J Cell Biol. 2010 Jan 11;188(1):7-9. doi: 10.1083/jcb.200912028.
Cell division depends critically on the temporally controlled assembly of mitotic spindles, which are responsible for the distribution of duplicated chromosomes to each of the two daughter cells. To gain insight into the process, Vizeacoumar et al., in this issue (Vizeacoumar et al. 2010. J. Cell Biol. doi:10.1083/jcb.200909013), have combined systems genetics with high-throughput and high-content imaging to comprehensively identify and classify novel components that contribute to the morphology and function of the mitotic spindle.
细胞分裂严重依赖于有丝分裂纺锤体的时间控制组装，纺锤体负责将复制的染色体分配到两个子细胞中的每一个。为了深入了解这个过程，Vizeacoumar 等人在本期杂志（Vizeacoumar 等人，2010. J. Cell Biol. doi:10.1083/jcb.200909013）中，将系统遗传学与高通量和高内涵成像相结合，全面鉴定和分类有助于有丝分裂纺锤体形态和功能的新成分。
