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CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

作者信息

Carpenter Anne E, Jones Thouis R, Lamprecht Michael R, Clarke Colin, Kang In Han, Friman Ola, Guertin David A, Chang Joo Han, Lindquist Robert A, Moffat Jason, Golland Polina, Sabatini David M

机构信息

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

出版信息

Genome Biol. 2006;7(10):R100. doi: 10.1186/gb-2006-7-10-r100. Epub 2006 Oct 31.

DOI:10.1186/gb-2006-7-10-r100
PMID:17076895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1794559/
Abstract

Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler. CellProfiler can address a variety of biological questions quantitatively, including standard assays (for example, cell count, size, per-cell protein levels) and complex morphological assays (for example, cell/organelle shape or subcellular patterns of DNA or protein staining).

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/5d5aa3ff61ef/gb-2006-7-10-r100-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/78595f43dc93/gb-2006-7-10-r100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/b113f2c3c83c/gb-2006-7-10-r100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/b1ec38792941/gb-2006-7-10-r100-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/5d5aa3ff61ef/gb-2006-7-10-r100-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/78595f43dc93/gb-2006-7-10-r100-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/b113f2c3c83c/gb-2006-7-10-r100-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/b1ec38792941/gb-2006-7-10-r100-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b915/1794559/5d5aa3ff61ef/gb-2006-7-10-r100-4.jpg

相似文献

[1]
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

Genome Biol. 2006

[2]
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[3]
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[4]
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[5]
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[7]
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[8]
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[9]
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[10]
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PLoS Biol. 2018-7-3

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本文引用的文献

[1]
Multiplexed high content screening assays create a systems cell biology approach to drug discovery.

Drug Discov Today Technol. 2005

[2]
CellProfiler: free, versatile software for automated biological image analysis.

Biotechniques. 2007-1

[3]
In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication.

Nat Genet. 2006-12

[4]
Genetic architecture of Hsp90-dependent drug resistance.

Eukaryot Cell. 2006-12

[5]
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.

Nat Methods. 2006-7

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Med Image Comput Comput Assist Interv. 2005

[7]
Small molecule screening by imaging.

Curr Opin Chem Biol. 2006-6

[8]
High-throughput RNAi screening in cultured cells: a user's guide.

Nat Rev Genet. 2006-5

[9]
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Cell. 2006-3-24

[10]
Identification of pathways regulating cell size and cell-cycle progression by RNAi.

Nature. 2006-2-23

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