Deneris E S, Connolly J, Rogers S W, Duvoisin R
Case Western Reserve University, School of Medicine, Department of Neuroscience, Cleveland, OH 44106.
Trends Pharmacol Sci. 1991 Jan;12(1):34-40. doi: 10.1016/0165-6147(91)90486-c.
Recent molecular cloning studies have identified several genes encoding alpha and beta subunits of the nicotinic acetylcholine receptor. These genes have distinct, although overlapping, patterns of expression in the brain and peripheral ganglia. Multiple nicotinic receptors with distinct pharmacological and functional properties can be made in oocytes by pairwise combination of different alpha-type subunits with different beta-type subunits. Both alpha and beta subunits contribute to the pharmacological and functional diversity. Evan Deneris and colleagues explain how oocyte expression studies, in concert with immunological and electrophysiological analysis in vivo, are beginning to reveal the subunit compositions of different neuronal nicotinic receptor subtypes.
最近的分子克隆研究已经鉴定出几个编码烟碱型乙酰胆碱受体α和β亚基的基因。这些基因在大脑和外周神经节中具有独特的表达模式，尽管存在重叠。通过将不同的α型亚基与不同的β型亚基进行两两组合，可以在卵母细胞中产生具有不同药理学和功能特性的多种烟碱型受体。α和β亚基都对药理学和功能多样性有贡献。埃文·德内里斯及其同事解释了卵母细胞表达研究如何与体内的免疫学和电生理学分析相结合，开始揭示不同神经元烟碱型受体亚型的亚基组成。
