Karakaya Pakize, Yiş Uluç, Kurul Semra Hz, Türkmen Mehmet Atilla
Department of Pediatric, School of Medicine, Dokuz Eylül University, Izmir, Turkey.
Pediatr Emerg Care. 2010 Jan;26(1):41-2. doi: 10.1097/PEC.0b013e3181c39a22.
Children with autism often display difficult behaviors including tantrums, extreme irritability, and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.
患有自闭症的儿童常常表现出一些棘手的行为，包括发脾气、极度易怒和身体攻击行为。越来越多的证据表明，奥氮平在减少这些破坏性行为方面是有用的。最常见的不良反应是体重增加和短期镇静作用。另一方面，奥氮平很少引起横纹肌溶解症。我们报告了一例自闭症儿童在接受两剂奥氮平治疗后发生横纹肌溶解症的病例。初始肌酸激酶值为30690 IU/L（范围为5 - 130 U/L），通过补液和碱化治疗，横纹肌溶解症在7天内得到缓解。在奥氮平治疗开始后的儿科病例中，监测血清肌酸激酶水平可能会有帮助。
