奥氮平诱发低钠血症和横纹肌溶解症。
Olanzapine induced hyponatremia and rhabdomyolysis.
作者信息
Younes N'joumi, Yassine Haimeur, Yassine El Harfaoui, Abdelkader Benhlima, Hamza Elhamzaoui, Mustapha Alilou
机构信息
Emergency Department, IBN SINA Hospital, Faculty of Medicine and Pharmacy University Mohammed V Rabat Morocco.
出版信息
Clin Case Rep. 2023 Feb 28;11(2):e5951. doi: 10.1002/ccr3.5951. eCollection 2023 Feb.
Abstract
Rapid-onset hyponatremia and rhabdomyolysis are rare, but potential, complications of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with an inappropriate antidiuretic hormone secretion syndrome. We report a case of sudden-onset hyponatremia associated with a severe rhabdomyolysis resulting in a coma-necessitating intensive care unit admission. His evolution was favorable after correction of all his metabolic disorders and olanzapine suspension.
摘要
快速发作的低钠血症和横纹肌溶解症虽罕见，但却是奥氮平治疗潜在的并发症。继发于非典型抗精神病药物使用的低钠血症在许多病例报告中都有记载，被认为与抗利尿激素分泌异常综合征有关。我们报告一例突发低钠血症伴严重横纹肌溶解症导致昏迷而需入住重症监护病房的病例。在纠正其所有代谢紊乱并停用奥氮平后，他的病情好转。
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