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本文引用的文献

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Hyponatraemia as an adverse drug reaction of antipsychotic drugs: a case-control study in VigiBase.抗精神病药的不良反应低钠血症：VigiBase 中的病例对照研究。
Drug Saf. 2010 Jul 1;33(7):569-78. doi: 10.2165/11532560-000000000-00000.
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[Hyponatremia: from physiopathology to practice].[低钠血症：从病理生理学到临床实践]
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Rhabdomyolysis associated with olanzapine treatment in a child with Autism.一名自闭症儿童在接受奥氮平治疗时出现横纹肌溶解症。
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[Olanzapine induced rhabdomyolysis and serum creatine kinase increase].奥氮平诱发横纹肌溶解症及血清肌酸激酶升高
Rev Med Interne. 2009 Jun;30(6):477-85. doi: 10.1016/j.revmed.2008.12.024.
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The pharmacovigilance of olanzapine: results of a post-marketing surveillance study on 8858 patients in England.奥氮平的药物警戒：对英国8858例患者的上市后监测研究结果
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Olanzapine-induced rhabdomyolysis.奥氮平所致横纹肌溶解症。
Ann Pharmacother. 2001 Sep;35(9):1020-3. doi: 10.1345/aph.10370.
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Massive serum creatine kinase increases with atypical antipsychotic drugs: what is the mechanism and the message?非典型抗精神病药物导致血清肌酸激酶大量升高：机制及启示是什么？
Psychopharmacology (Berl). 2000 Jun;150(3):349-50. doi: 10.1007/s002130000465.
8
Olanzapine. A review of its pharmacological properties and therapeutic efficacy in the management of schizophrenia and related psychoses.奥氮平。对其治疗精神分裂症及相关精神病的药理特性和疗效的综述。
Drugs. 1997 Feb;53(2):281-98. doi: 10.2165/00003495-199753020-00007.
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The syndrome of inappropriate secretion of antidiuretic hormone.抗利尿激素分泌不当综合征
Am J Med. 1967 May;42(5):790-806. doi: 10.1016/0002-9343(67)90096-4.
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Inhibitory role of periventricular dopaminergic mechanisms in hemorrhage-induced vasopressin secretion in conscious rats.脑室周围多巴胺能机制对清醒大鼠出血诱导的血管加压素分泌的抑制作用。
Brain Res. 1990 Apr 16;513(2):335-8. doi: 10.1016/0006-8993(90)90477-s.

奥氮平诱发低钠血症和横纹肌溶解症。

Olanzapine induced hyponatremia and rhabdomyolysis.

作者信息

Younes N'joumi, Yassine Haimeur, Yassine El Harfaoui, Abdelkader Benhlima, Hamza Elhamzaoui, Mustapha Alilou

机构信息

Emergency Department, IBN SINA Hospital, Faculty of Medicine and Pharmacy University Mohammed V Rabat Morocco.

出版信息

Clin Case Rep. 2023 Feb 28;11(2):e5951. doi: 10.1002/ccr3.5951. eCollection 2023 Feb.

DOI:10.1002/ccr3.5951
PMID:36865653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9972862/
Abstract

Rapid-onset hyponatremia and rhabdomyolysis are rare, but potential, complications of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with an inappropriate antidiuretic hormone secretion syndrome. We report a case of sudden-onset hyponatremia associated with a severe rhabdomyolysis resulting in a coma-necessitating intensive care unit admission. His evolution was favorable after correction of all his metabolic disorders and olanzapine suspension.

摘要

快速发作的低钠血症和横纹肌溶解症虽罕见，但却是奥氮平治疗潜在的并发症。继发于非典型抗精神病药物使用的低钠血症在许多病例报告中都有记载，被认为与抗利尿激素分泌异常综合征有关。我们报告一例突发低钠血症伴严重横纹肌溶解症导致昏迷而需入住重症监护病房的病例。在纠正其所有代谢紊乱并停用奥氮平后，他的病情好转。