成功的衡量标准:形态发生素介导的模式形成中的约束、目标和权衡。

The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterning.

机构信息

Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA.

出版信息

Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a002022. doi: 10.1101/cshperspect.a002022.

Abstract

A large, diverse, and growing number of strategies have been proposed to explain how morphogen gradients achieve robustness and precision. We argue that, to be useful, the evaluation of such strategies must take into account the constraints imposed by competing objectives and performance tradeoffs. This point is illustrated through a mathematical and computational analysis of the strategy of self-enhanced morphogen clearance. The results suggest that the usefulness of this strategy comes less from its ability to increase robustness to morphogen source fluctuations per se, than from its ability to overcome specific kinds of noise, and to increase the fraction of a morphogen gradient within which robust threshold positions may be established. This work also provides new insights into the longstanding question of why morphogen gradients show a maximum range in vivo.

摘要

已经提出了大量多样化且不断增加的策略来解释形态发生梯度如何实现稳健性和精确性。我们认为,为了有用,对这些策略的评估必须考虑到竞争目标和性能权衡带来的限制。通过对自增强形态发生物清除策略的数学和计算分析来说明了这一点。结果表明,该策略的有用性与其本身增加对形态发生物源波动的稳健性的能力相比,不如说是来自于它克服特定类型噪声的能力,以及增加了可以建立稳健阈值位置的形态发生物梯度的一部分。这项工作还为长期存在的问题提供了新的见解,即为什么形态发生物梯度在体内表现出最大范围。

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