Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.
Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a001255. doi: 10.1101/cshperspect.a001255.
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.
形态发生梯度在靶组织中是如何形成的,这是理解形态发生模式机制的关键问题。在这里,我们从理论和实验的角度回顾了形态发生梯度形成的不同机制。首先,提供了对几种梯度形成机制的基础生物物理原理的简单而全面的概述。然后,我们讨论了不同实验方法在梯度形成分析中的优缺点。