Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands.
Eur J Epidemiol. 2010 Feb;25(2):103-13. doi: 10.1007/s10654-009-9416-x.
We assessed reliability of self-reported diagnostic radiation history in BRCA1/2 mutation carriers with and without breast cancer. Within the frame-work of the HEBON study, 401 BRCA1/2 mutation carriers completed a baseline (1999-2004) and a follow-up questionnaire (2006-2007). Test-retest reliability of self-reported exposure to chest X-rays, fluoroscopies and mammograms was assessed for the entire study population and by case status.Overall proportion agreement on reporting ever/never exposure was good ([75%), while the corresponding kappa coefficients were between 0.40 and 0.75, indicating at least moderate reliability beyond chance. Reliability of number of exposures was also good ([75%). Proportion agreement on reporting age at first mammogram was low(40%) for exact consistency and moderate (60%) for consistency +/- 1 year. Reliability of age at first mammogram was higher for cases than for unaffected carriers(P\0.001) but this difference disappeared when excluding diagnostic mammograms (P = 0.60). In unaffected carriers proportion agreement on age at last mammogram was 50%. In general, the direction of disagreement on all items was equally distributed. More consistent reporting was mainly determined by a younger age at questionnaire completion. In conclusion, inconsistent self-report of diagnostic radiation by BRCA1/2 mutation carriers was mainly non-differential by disease status.
我们评估了有和没有乳腺癌的 BRCA1/2 突变携带者自我报告的诊断性辐射史的可靠性。在 HEBON 研究框架内，401 名 BRCA1/2 突变携带者完成了基线（1999-2004 年）和随访问卷（2006-2007 年）。对整个研究人群和病例状态评估了自我报告暴露于胸部 X 光、透视和乳房 X 线照片的测试重测可靠性。报告是否曾经暴露的总体比例一致性良好（[75%），而相应的 Kappa 系数在 0.40 到 0.75 之间，表明除了机会之外，至少具有中度可靠性。暴露次数的可靠性也很好（[75%）。对于确切的一致性，报告首次乳房 X 线照片的年龄的比例一致性低（40%），对于一致性 +/-1 年，比例一致性适中（60%）。与未受影响的携带者相比，病例的首次乳房 X 线照片年龄的可靠性更高（P\0.001），但在排除诊断性乳房 X 线照片时，这种差异消失（P=0.60）。在未受影响的携带者中，最后一次乳房 X 线照片年龄的比例一致性为 50%。一般来说，所有项目的不一致报告方向分布均匀。更一致的报告主要由问卷完成时的年龄较小决定。总之，BRCA1/2 突变携带者对诊断性辐射的不一致自我报告主要与疾病状态无关。
