Fagard R
Labo Hartfunctie, Pellenberg, Belgium.
Am J Med. 1991 Mar;90(3A):62S-63S. doi: 10.1016/0002-9343(91)90440-9.
The relation between serum cholesterol and mortality was investigated in 822 elderly hypertensive patients randomly assigned to treatment with diuretics, with or without methyldopa, or placebo. Cox's proportional hazards model showed that pretreatment serum total cholesterol levels were independently and inversely correlated with total mortality (p = 0.03), noncardiovascular mortality (p = 0.02), and cancer mortality (p = 0.04) during treatment. Total and noncardiovascular mortality were also negatively correlated with pretreatment hemoglobin levels and body weight. All factors being equal, an increase in total serum cholesterol of 2.3 mmol/L was associated with a one-year prolongation of survival. After adjustment for gender, age, pretreatment cardiovascular complications, and systolic pressure, the correlations between serum cholesterol and cardiovascular and cardiac mortality were not significant.
对822例老年高血压患者进行了研究，这些患者被随机分配接受利尿剂治疗，联合或不联合甲基多巴，或接受安慰剂治疗，以探讨血清胆固醇与死亡率之间的关系。Cox比例风险模型显示，治疗前血清总胆固醇水平与治疗期间的总死亡率（p = 0.03）、非心血管死亡率（p = 0.02）和癌症死亡率（p = 0.04）独立且呈负相关。总死亡率和非心血管死亡率也与治疗前血红蛋白水平和体重呈负相关。在其他因素相同的情况下，血清总胆固醇每增加2.3 mmol/L，生存期延长一年。在对性别、年龄、治疗前心血管并发症和收缩压进行校正后，血清胆固醇与心血管和心脏死亡率之间的相关性不显著。
