Staessen J
Klinish Laboratorium Hypertensie, Leuven, Belgium.
Am J Med. 1991 Mar;90(3A):60S-61S. doi: 10.1016/0002-9343(91)90439-5.
Elderly hypertensive patients were randomly assigned to treatment with diuretics and methyldopa (n = 352) or placebo (n = 339), and divided into three groups, each according to their blood pressures, after nine months of treatment. Subsequently, 65 placebo patients and 56 treated patients died. A U-shaped relation was seen in treated patients between mortality and systolic blood pressure, and in placebo patients between mortality and diastolic blood pressure. Whereas in treated patients, the highest mortality was seen in patients with the lowest diastolic pressure, the lowest mortality was seen in the group with the highest diastolic pressure. The increased mortality in treated patients with the lowest blood pressure may not be drug-induced, but an expression of deterioration in general health, as indicated by the decreases in body weight and hemoglobin levels found in patients with the lowest blood pressures in previous analyses of these data.
老年高血压患者被随机分配接受利尿剂和甲基多巴治疗（n = 352）或安慰剂治疗（n = 339），治疗九个月后，根据血压将其分为三组。随后，65名接受安慰剂治疗的患者和56名接受治疗的患者死亡。在接受治疗的患者中，死亡率与收缩压之间呈U形关系；在接受安慰剂治疗的患者中，死亡率与舒张压之间呈U形关系。在接受治疗的患者中，舒张压最低的患者死亡率最高，而舒张压最高的组死亡率最低。血压最低的接受治疗患者死亡率增加可能并非药物所致，而是总体健康状况恶化的表现，此前对这些数据的分析发现，血压最低的患者体重和血红蛋白水平下降就表明了这一点。
