Wibowo Candra, Kaparang A M C Karema, Moeis Emma Sy, Kapojos A L
Division of Renal Hypertension, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/ Prof. dr. Kandou Central General Hospital, Manado.
Acta Med Indones. 2005 Apr-Jun;37(2):61-65.
Determine renal function and factors that influence reduction in renal function among Minahasanese with chronic gout arthritis and tophi.
This is a descriptive cross-sectional study where study subjects are recruited using multi-stage sampling. The data are descriptively processed using T-test, Pearson correlates, and multiple regression analysis.
The proportion of mild, moderate, and severe reductions in renal function in Minahasanese with chronic gout arthritis and tophi were as follows: 25 patients (69.7%), 7 patients (19.5%), and 5 patients (11%). According to Pearson correlation, only urinary uric acid excretion (r=0.626, p=0.000). The same findings were found using multiple regression, only urinary uric acid excretion is significant (p=0.001).
Most Minahasanese with chronic gout arthritis and tophi suffer from a mild reduction in renal function associated with the amount of uric acid excreted in the urine, but not associated with age, serum uric acid level, duration of gout arthritis, or tophi. Correlation with duration of gout arthritis, or tophi. Correlation with hypertension and use of NSAID are not evident in this study.
确定患有慢性痛风性关节炎和痛风石的米纳哈萨人肾功能及影响肾功能减退的因素。
这是一项描述性横断面研究，采用多阶段抽样招募研究对象。数据采用t检验、Pearson相关性分析和多元回归分析进行描述性处理。
患有慢性痛风性关节炎和痛风石的米纳哈萨人肾功能轻度、中度和重度减退的比例如下：25例（69.7%）、7例（19.5%）和5例（11%）。根据Pearson相关性分析，仅尿尿酸排泄量相关（r = 0.626，p = 0.000）。多元回归分析得到相同结果，仅尿尿酸排泄量具有显著性（p = 0.001）。
大多数患有慢性痛风性关节炎和痛风石的米纳哈萨人肾功能轻度减退，与尿中尿酸排泄量有关，但与年龄、血清尿酸水平、痛风性关节炎病程或痛风石无关。本研究未发现与痛风性关节炎病程或痛风石的相关性。本研究中未发现与高血压和使用非甾体抗炎药的相关性。
