Youssef P, Brama T, York H, Pickard P, Stewart P, McGill N
Combined Centre for Rheumatic Diseases, Rachel Forster and Royal Prince Alfred Hospitals, Sydney, NSW, Australia.
J Rheumatol. 1995 Mar;22(3):494-6.
To test whether renal impairment protects from the development of gout.
We conducted a retrospective cohort study in which 40 hyperuricemic patients (serum uric acid > 0.54 mM/l) with renal impairment (serum creatinine > 200 microM/l) and 40 equally hyperuricemic patients with normal renal function (serum creatinine < 120 microM/l) were given a telephone questionnaire eliciting a history of gout, its pattern and severity, and other features of medical and family history.
There was no significant difference among the prevalence of gout (relative risk 1.1, confidence interval 0.73-1.67), the pattern and severity of gout, and the presence of tophi between the 2 groups. A positive family history of gout was significantly increased in the patients with gouty arthritis (p < 0.05).
Renal impairment does not protect from gout. There may be a familial factor in the development of gout that is independent from the familial tendency for hyperuricemia.
检验肾功能损害是否能预防痛风的发生。
我们进行了一项回顾性队列研究，对40例肾功能损害（血清肌酐>200微摩尔/升）的高尿酸血症患者（血清尿酸>0.54毫摩尔/升）和40例肾功能正常（血清肌酐<120微摩尔/升）的同等高尿酸血症患者进行电话问卷调查，了解痛风病史、其模式和严重程度以及其他病史和家族史特征。
两组之间痛风患病率（相对风险1.1，置信区间0.73 - 1.67）、痛风模式和严重程度以及痛风石的存在情况均无显著差异。痛风性关节炎患者的痛风家族史阳性率显著增加（p<0.05）。
肾功能损害不能预防痛风。痛风的发生可能存在一个独立于高尿酸血症家族倾向的家族因素。
