Department of Anesthesiology, Weill Medical College of Cornell University, 1300 York Avenue, LC-206, New York, NY 10021, USA.
Thorac Surg Clin. 2009 Aug;19(3):345-51. doi: 10.1016/j.thorsurg.2009.06.006.
As the population ages, increasing numbers of elderly patients will present with lung cancer. Due to recent advances in neoadjuvant therapies and accumulating data demonstrating a favorable risk/benefit relationship even in octogenarians, more of these geriatric patients will be surgical candidates. Although preoperative functional status and comorbidities seem to have more of an influence on outcome than age alone, the normal process of cardiopulmonary aging can serve to limit the physiologic reserve necessary to compensate for perioperative stress even in otherwise healthy elderly patients. Emerging experience now also suggests that minimally invasive surgical techniques for the treatment of lung cancer may parallel conventional thoracotomy in terms of oncologic efficacy while decreasing perioperative morbidity in the elderly.
随着人口老龄化,越来越多的老年肺癌患者将出现。由于新辅助治疗的进展以及越来越多的数据表明即使在 80 岁以上的患者中也具有良好的风险/获益关系,更多的老年患者将成为手术候选人。尽管术前功能状态和合并症对结果的影响似乎比年龄本身更大,但心肺衰老的正常过程可能会限制即使在其他方面健康的老年患者中也能补偿围手术期应激所需的生理储备。目前的新经验还表明,对于肺癌的微创外科治疗技术在肿瘤疗效方面可以与传统的开胸手术相媲美,同时减少老年患者的围手术期发病率。