Dong Jie, Zhu Huaxu, Guo Liwei
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(19):2458-62.
The UF process of model systerm of Huanglian Jiedu decoction is researched in the study to lay a foundation for the exploring of the substance foudation of membrane fouling, and for the the optimal design of membrane technology in the production of Chinese drugs preparation.
Using the membrane flux, fouling degree of membrane, preserving degree and adsorption capacity of effective materials as guide line, trying to find out the influence of macromolecule materials on small molecules in Huanglian Jiedu decoction.
The two small molecules berberine and gardenoside in Huanglian Jiedu decoction have high permeation rate. But for the reasons of interaction of macromolecule, the permeation rate of small molecules reduced greatly, membrane fouling and membrane flux declined intensify.
Starch and pectin are the two main macromolecule materials in Huanglian Jiedu decoction which cause membrane fouling and flux falling.
本研究对黄连解毒汤模型体系的超滤过程进行研究，为探索膜污染的物质基础以及中药制剂生产中膜技术的优化设计奠定基础。
以膜通量、膜污染程度、有效物质保留率和吸附量为指标，探究黄连解毒汤中大分子物质对小分子物质的影响。
黄连解毒汤中的两种小分子物质黄连素和栀子苷具有较高的透过率。但由于大分子物质的相互作用，小分子物质的透过率大幅降低，膜污染加剧，膜通量下降。
淀粉和果胶是黄连解毒汤中导致膜污染和通量下降的两种主要大分子物质。
