Zhou Jing, Sun Jia-Yu, Sun Jia-Guan, Lin Liu, Yong Xu, Jiang Hong
Clinical Laboratory Medical Department, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Nov;40(6):1078-81.
To evaluate the diagnostic performance of five D-dimer assays for the exclusion of suspected venous thromboembolis (VTE).
The plasma D-dimer levels of 75 suspected VTE patients were tested with ELISA, VIDAS DD, DD Plus, Liatest STAGO DD, and NycoCard DD. The results of the five assays were compared with the gold standard of diagnosis of VTE.
Liatest STAGO DD, DD Plus, VIDAS DD and ELISA had good diagnostic performance for the exclusion of suspected VTE. Liatest STAGO DD had the greatest accuracy for differentiating diagnosis, with 0.814 of area under the curve (AUC), 96.7% of sensitivity, and 95.5% of negative predictive value. ELISA had the greatest specificity (48.9%). The five assays showed good correlations, with VIDAS DD and Liatest STAGO DD having the greatest correlation coefficient (r = 0.9106). VIDAS DD and Liatest STAGO DD correlated well with ELISA (r = 0.8764 and r = 0.8360 respectively).
Liatest STAGO DD, DD Plus, and VIDAS DD have good diagnostic performance for the exclusion of VTE. They are easier and quicker to perform and can serve as an alternative test for ELISA. Further validation is needed for clinical applications.
评估五种D - 二聚体检测方法用于排除疑似静脉血栓栓塞症（VTE）的诊断性能。
采用酶联免疫吸附测定法（ELISA）、VIDAS D - 二聚体检测法、D - 二聚体增强检测法、Liatest STAGO D - 二聚体检测法和NycoCard D - 二聚体检测法对75例疑似VTE患者的血浆D - 二聚体水平进行检测。将这五种检测方法的结果与VTE诊断的金标准进行比较。
Liatest STAGO D - 二聚体检测法、D - 二聚体增强检测法、VIDAS D - 二聚体检测法和ELISA在排除疑似VTE方面具有良好的诊断性能。Liatest STAGO D - 二聚体检测法在鉴别诊断方面准确性最高，曲线下面积（AUC）为0.814，灵敏度为96.7%，阴性预测值为95.5%。ELISA具有最高的特异性（48.9%）。这五种检测方法显示出良好的相关性，VIDAS D - 二聚体检测法和Liatest STAGO D - 二聚体检测法的相关系数最大（r = 0.9106）。VIDAS D - 二聚体检测法和Liatest STAGO D - 二聚体检测法与ELISA的相关性良好（分别为r = 0.8764和r = 0.8360）。
Liatest STAGO D - 二聚体检测法、D - 二聚体增强检测法和VIDAS D - 二聚体检测法在排除VTE方面具有良好的诊断性能。它们操作更简便、快速，可作为ELISA的替代检测方法。临床应用还需要进一步验证。
