Cope Steven M, Liu Xue-Cheng, Verber Matthew D, Cayo Christine, Rao Stephen, Tassone J Channing
Concordia University Wisconsin, Rehabilitation Science, Mequon, WI 53097, USA.
Dev Neurorehabil. 2010 Feb;13(1):19-30. doi: 10.3109/17518420903236247.
The aims of this study were to (1) investigate the effectiveness of CIMT for children with hemiplegia, (2) determine the feasibility of using fMRI for describing brain activity patterns before and after CIMT and (3) describe changes in brain reorganization after CIMT in children with hemiplegia using fMRI.
Before and after study with one group.
Ten children aged 7-14 years (M = 11.0, SD = 2.5) with hemiplegia received CIMT over a 2-week period using a before and after design. Clinical measures included the Melbourne Assessment of Unilateral Upper Limb Function, upper limb kinematics and parent questionnaire. Children were measured with fMRI before and after CIMT.
Findings showed that CIMT may be effective at improving upper limb function in some, but not all children; those children with a moderate degree of impairment seemed to benefit the most. fMRI findings correlated moderately with clinical measures.
Although unique challenges with fMRI data collection exist for this population, it provides potentially valuable information to better understand mechanisms of change after interventions such as CIMT.
本研究的目的是：（1）调查强制性诱导运动疗法（CIMT）对偏瘫儿童的有效性；（2）确定使用功能磁共振成像（fMRI）描述CIMT前后脑活动模式的可行性；（3）使用fMRI描述偏瘫儿童CIMT后脑重组的变化。
一组前后对照研究。
10名年龄在7至14岁（平均年龄M = 11.0，标准差SD = 2.5）的偏瘫儿童采用前后对照设计，在2周内接受CIMT。临床测量包括墨尔本单侧上肢功能评估、上肢运动学和家长问卷。儿童在CIMT前后接受fMRI测量。
研究结果表明，CIMT可能对部分而非全部儿童的上肢功能改善有效；中度受损的儿童似乎受益最大。fMRI结果与临床测量结果中度相关。
尽管该人群在fMRI数据收集方面存在独特挑战，但它为更好地理解CIMT等干预措施后的变化机制提供了潜在的有价值信息。
