“RASor”的优势：关节炎中的 Ras 蛋白和基质破坏。
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis.
出版信息
Arthritis Res Ther. 2009;11(6):136. doi: 10.1186/ar2840. Epub 2009 Dec 11.
Abstract
The shared characteristics of rheumatoid arthritis (RA) and cancer, particularly their unchecked growth and invasive behaviors, have been apparent for some time. However, the molecular mechanisms underlying these similarities are not clear. In a recent issue of Arthritis Research & Therapy, Abreu and colleagues link a well-studied oncogene, Ras, with expression of matrix metalloproteinase-3 (MMP-3) in RA. Their study correlates expression of the Ras guanine nucleotide exchange factor RasGRF1 with MMP-3 expression in RA synovium. They elucidate a potential mechanism of regulation of MMP-3 expression in RA, suggesting a potential target for RA treatment.
摘要
类风湿关节炎 (RA) 和癌症具有一些共同特征，尤其是它们不受控制的生长和侵袭行为，这一点已经很明显了。然而，这些相似之处的分子机制尚不清楚。在最近一期的《关节炎研究与治疗》杂志上，Abreu 及其同事将一个研究充分的癌基因 Ras 与 RA 中的基质金属蛋白酶-3 (MMP-3) 的表达联系起来。他们的研究将 Ras 鸟嘌呤核苷酸交换因子 RasGRF1 的表达与 RA 滑膜中的 MMP-3 表达相关联。他们阐明了 RA 中 MMP-3 表达的潜在调节机制，提示 RA 治疗的一个潜在靶点。
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本文引用的文献
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Arthritis Res Ther. 2009;11(4):R121. doi: 10.1186/ar2785. Epub 2009 Aug 13.
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