Cingoz Oya
Department of Molecular Biology and Microbiology; Tufts University School of Medicine; Boston, MA 02111, USA.
MAbs. 2009 May-Jun;1(3):216-21. doi: 10.4161/mabs.1.3.8593.
Ustekinumab is an anti-IL12/23 IgG1 kappa human monoclonal antibody currently undergoing US Food and Drug Administration review for use as a psoriasis treatment. The candidate has also been evaluated in Phase 2 studies as a treatment for psoriatic arthritis, Crohn disease and multiple sclerosis.In large clinical trials, ustekinumab has proven effective for treating moderate to severe plaque psoriasis. Although long-term follow-up studies are needed to address safety concerns, the hopes are high for psoriasis treatment. Ustekinumab has recently been approved for marketing in Canada and Europe.
优特克单抗是一种抗白细胞介素12/23的IgG1κ人源单克隆抗体,目前正在接受美国食品药品监督管理局的审查,用于治疗银屑病。该候选药物也已在2期研究中作为银屑病关节炎、克罗恩病和多发性硬化症的治疗方法进行了评估。在大型临床试验中,优特克单抗已被证明对治疗中度至重度斑块状银屑病有效。尽管需要长期随访研究来解决安全问题,但治疗银屑病的前景十分乐观。优特克单抗最近已在加拿大和欧洲获批上市。