Wang Yan, Lu Chengping
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
Wei Sheng Wu Xue Bao. 2009 Oct;49(10):1277-81.
Phage endolysin targets the integrate cell wall and attack bonds in the peptidoglycan, resulting in degradation of bacteria. It features two or three domain structures, involving one or two catalytic domains and one binding domain. Endolysin is a promising antibiotic agent against gram-positive bacteria pathogen, such as Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus. Compared to antibiotics, it is more specific and tested bacteria show no resistance to lysin. Therefore, it's a feasible measure for solving drug resistant problem. Beyond this, it is highly active and rapid lysis efficiency and has synergy effect when used together or with other antibiotics. Antibody against endolysin will not neutralize its activity. So endolysin treatment may be a new approach for preventing and controlling of bacteria pathogen.
噬菌体溶菌酶作用于完整的细胞壁，攻击肽聚糖中的化学键，从而导致细菌降解。它具有两个或三个结构域，包括一个或两个催化结构域和一个结合结构域。溶菌酶是一种有前景的抗革兰氏阳性菌病原体的抗生素，如肺炎链球菌、化脓性链球菌和金黄色葡萄球菌。与抗生素相比，它更具特异性，且受试细菌对溶菌酶无抗性。因此，它是解决耐药性问题的一种可行措施。除此之外，它具有高活性和快速裂解效率，与其他抗生素联合使用时具有协同效应。抗溶菌酶抗体不会中和其活性。所以溶菌酶治疗可能是预防和控制细菌病原体的一种新方法。
