Zhang Qiang, Feng Yingying, Zhou Qingchun, Luo Qin, Zhang Xiaoli, Qin Longjuan
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China.
Wei Sheng Wu Xue Bao. 2009 Oct;49(10):1282-8.
The alternative sigma factor Sigma B plays important roles in both virulence and stress tolerance in Listeria monocytogenes. It is now clear that there is a strong link between the virulence potential of Listeria monocytogenes and its ability to tolerate stress. Several studies have identified genes that play important roles in stress tolerance and virulence. For example, genes involved in osmotic stress tolerance, acid and alkaline tolerance, oxidative stress tolerance, extreme temperature tolerance, and bile salt tolerance have all been implicated in the virulence of L. monocytogenes. We reviewed the role of Sigma B in several environmental stress conditions to understand the physical character of this microorganism, to discuss the best preservation conditions of food, and to prevent bacterial infection.
替代性σ因子Sigma B在单核细胞增生李斯特菌的毒力和应激耐受性方面均发挥着重要作用。目前很清楚的是，单核细胞增生李斯特菌的毒力潜能与其耐受应激的能力之间存在紧密联系。多项研究已鉴定出在应激耐受性和毒力方面发挥重要作用的基因。例如，参与渗透压耐受性、酸碱耐受性、氧化应激耐受性、极端温度耐受性和胆盐耐受性的基因均与单核细胞增生李斯特菌的毒力有关。我们综述了Sigma B在几种环境应激条件下的作用，以了解这种微生物的物理特性，探讨食品的最佳保存条件，并预防细菌感染。
