[Preparation and characterization of oridonin submicron emulsions].

OBJECTIVE

To prepare the oridonin submicron emulsion and characterize their properties.

METHOD

High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size, Zeta potential and viscosity were characterized.

RESULT

The results showed that the submicron emulsions was formed with the drug loading 1 g L(-1), particle size of (138.87 +/- 0.60) nm, zeta potential of (47.27 +/- 2.31) mV, pH value of (6.02 +/- 0.03) and viscosity of (1.78 +/- 0.015) MPa s, respectively.

CONCLUSION

The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.