Wu Suxiang, Lv Guiyuan, Chen Suhong, Zhang Shengna, Zhao Lishan, Zhou Rihe, Zhou Huakang
Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhongguo Zhong Yao Za Zhi. 2009 Dec;34(24):3199-202.
To prepare the submicron emulsion of fresh Zhongjiefeng volatile oil.
The Zhongjiefeng volatile oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer. The physical and chemical stability of the emulsion was evaluated with the stability parameter of centrifugation, appearance of emulsion and the pH. The formulation and processing factors were optimized by single factor reviewing and orthogonal experimental design.
By controlling various processing factors and optimizing formulation, the stable submicron emulsion of Zhongjiefeng volatile oil was prepared. Its mean particle diameter was 164-169 nm with PDI 0.084-0.107 and Zeta electric potential was -40 mV.
The formulation and preparation technique of the emulsion is reasonable.
制备鲜肿节风挥发油亚微乳。
初乳经高压均质机处理后得到肿节风挥发油亚微乳。通过离心稳定参数、乳剂外观及pH值对乳剂的理化稳定性进行评价。采用单因素考察和正交试验设计对处方及工艺因素进行优化。
通过控制各种工艺因素并优化处方，制备出了稳定的肿节风挥发油亚微乳。其平均粒径为164 - 169nm，PDI为0.084 - 0.107，Zeta电位为 - 40mV。
该乳剂的处方及制备工艺合理。
