Chai Chengzhi, Kou Junping, Zhu Danni, Yan Yongqing, Yu Boyang
China Pharmaceutical Uiniversity, Nanjing, China.
Zhongguo Zhong Yao Za Zhi. 2009 Oct;34(20):2673-5.
Combination disease and syndrome to construct animal model must be accord with the diagnosis and treatment mode of tradition Chinese medicine (TCM). The construct ion method should abide by the mode of combination prescription, syndrome, disease and efficacy. Prescription refers to those classic and effective formula. Syndrome refers to the symptoms and signs of prescription. Disease refers to model medical disease. Efficacy refers to the results of treatment. Constructing animal model should choose the classical prescription and formulate the clinical signs and symptoms. According to the main pathological process of modem diseases related to the syndrome to mine the methods of constructing animal models to express the main signs and symptoms, at last to testify the efficacy through the corresponding prescription. This method of constructing animal model is not only accord to the mode of diagnosis and treatment of TCM, but also affords a certain example of constructing animal model of combination model disease and syndrome.
病证结合构建动物模型必须符合中医的诊疗模式。构建方法应遵循方证病效相结合的模式。方是指经典且有效的方剂。证是指方剂的症状和体征。病是指模型医学疾病。效是指治疗结果。构建动物模型应选择经典方剂并制定临床症状和体征。根据与证相关的现代疾病的主要病理过程挖掘构建动物模型的方法以表达主要症状和体征，最后通过相应方剂验证疗效。这种构建动物模型的方法不仅符合中医诊疗模式，而且为病证结合模型动物的构建提供了一定范例。
