CNRS, UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.
J Neuroendocrinol. 2010 Mar;22(3):209-16. doi: 10.1111/j.1365-2826.2010.01955.x. Epub 2010 Jan 7.
The hormones secreted by the anterior pituitary gland regulate major functions such as reproduction, as well as body growth and metabolism. Their efficiency of action highly depends on their temporal profile of release in the blood stream. This review summarises the recent evidence suggesting that the circadian clock genes that pace our daily rhythms may also contribute to the regulation of pituitary pulsatility, even in the non 24-h range. This inter-relation between molecular circadian oscillators and endocrine rhythmicities is discussed in light of the longstanding literature that has considered the involvement of the central circadian pacemaker located within the suprachiasmatic nuclei. Other arguments that suggest a role for circadian clock genes outside the suprachiasmatic nuclei are also presented, with a special emphasis on endocrine pituitary cells and hypothalamic neuroendocrine neurones that directly pace pituitary secretion rates.
脑垂体前叶分泌的激素调节着生殖等主要功能，以及身体的生长和新陈代谢。它们在血液中的释放时间模式对其作用效率有很大的影响。这篇综述总结了最近的证据，表明调节我们日常节律的生物钟基因也可能有助于调节脑垂体的脉冲式分泌，即使在非 24 小时范围内也是如此。本文讨论了分子生物钟振荡器和内分泌节律之间的这种相互关系，同时也考虑了位于视交叉上核内的中枢生物钟起搏器的长期文献。还提出了生物钟基因在视交叉上核之外发挥作用的其他论点，特别强调了直接调节脑垂体分泌率的内分泌垂体细胞和下丘脑神经内分泌神经元。
