Reghunandanan V, Reghunandanan R, Marya R K
Department of Physiology, Medical College Rohtak, Haryana, India.
Chronobiologia. 1991 Jan-Mar;18(1):39-47.
In this review article an insight has been made into the strong possibility of the role of vasopressin (VP) in the control of circadian rhythms which has emerged from the results of the recent experiments in this field. A role for VP, which is identified in the suprachiasmatic nuclei (SCN) of mammals, as a neurotransmitter/neuromodulator in the central nervous system has been postulated for some time now. The presence of certain abnormalities in the circadian rhythms in VP deficient Brattleboro rats has suggested that this neuropeptide is a likely candidate in controlling circadian rhythms. The coexistence of VP and corticotropin releasing factor (CRF), their interrelation with reference to their role in the hypothalamus-pituitary-adrenocortical glucocorticoid axis not only in states of stress but also in day-to-day life has also been discussed. The possible role of dynorphin, which is co-synthesized with VP in the hypothalamic neurons, and other opioids in the control of circadian rhythms has been highlighted. The pineal, SCN relation in the process of development of circadian rhythms has also been reviewed briefly.
在这篇综述文章中，基于该领域近期实验结果，深入探讨了血管加压素（VP）在控制昼夜节律方面发挥作用的极大可能性。VP在哺乳动物视交叉上核（SCN）中被发现，作为中枢神经系统中的一种神经递质/神经调节剂，其作用已被推测了一段时间。VP缺乏的布拉特洛维大鼠昼夜节律存在某些异常，这表明这种神经肽可能是控制昼夜节律的一个候选因素。文章还讨论了VP与促肾上腺皮质激素释放因子（CRF）的共存，以及它们在应激状态和日常生活中在下丘脑 - 垂体 - 肾上腺皮质糖皮质激素轴中的相互关系。文章强调了与VP在下丘脑神经元中共同合成的强啡肽以及其他阿片类物质在控制昼夜节律方面的可能作用。同时，也简要回顾了昼夜节律发育过程中松果体与SCN的关系。
