Psychiatry Department, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, and Sha'ar Menashe Mental Health Center, Israel.
CNS Neurosci Ther. 2010 Spring;16(1):32-44. doi: 10.1111/j.1755-5949.2009.00118.x.
Neurosteroids, such as pregnenolone (PREG), dehydroepiandrosterone (DHEA), and their sulfates (PREGS and DHEAS) are reported to have a modulatory effect on neuronal excitability and synaptic plasticity. They also have many other functions associated with neuroprotection, response to stress, mood regulation, and cognitive performance. Furthermore, these neurosteroids have been linked to, and their levels are altered in, neuropsychiatric disorders. This review highlights what is currently known about the metabolism and mode of action of PREG and DHEA, as well as about alterations of these neurosteroids in schizophrenia. This review also provides substantial information about clinical trials with DHEA and PREG augmentation with of antipsychotic agents in schizophrenia.
神经甾体，如孕烯醇酮（PREG）、脱氢表雄酮（DHEA）及其硫酸盐（PREGS 和 DHEAS），据报道对神经元兴奋性和突触可塑性具有调节作用。它们还有许多其他与神经保护、应激反应、情绪调节和认知表现相关的功能。此外，这些神经甾体已被证明与神经精神疾病有关，其水平也在这些疾病中发生改变。这篇综述强调了目前已知的 PREG 和 DHEA 的代谢和作用模式，以及精神分裂症中这些神经甾体的改变。这篇综述还提供了大量关于精神分裂症中使用 DHEA 和 PREG 与抗精神病药物联合增效的临床试验信息。
