Endocrine Research Laboratory, Aurora St, Luke's Medical Center, Milwaukee, WI 53215, USA.
Lipids Health Dis. 2010 Jan 13;9:3. doi: 10.1186/1476-511X-9-3.
The physiological and biochemical responses to acute hypoxia have not been fully characterized in neonates. Fatty acids and lipids play an important role in most aspects of cardiac function.
We performed comprehensive lipid profiling analysis to survey the changes that occur in heart tissue and plasma of neonatal and young adult rats exposed to hypoxia for 2 h, and following 2 h of recovery from hypoxia.
Cardiac and plasma concentrations of short-chain acylcarnitines, and most plasma long-chain fatty acids, were decreased in hypoxic neonates. Following recovery from hypoxia, concentrations of propionylcarnitine, palmitoylcarnitine, stearoylcarnitine were increased in neonatal hearts, while oleylcarnitine and linoleylcarnitine concentrations were increased in neonatal plasma. The concentrations of long-chain fatty acids and long-chain acylcarnitines were increased in the hearts and plasma of hypoxic young adult rats; these metabolites returned to baseline values following recovery from hypoxia.
There are differential effects of acute hypoxia on cardiac and plasma lipid profiles with maturation from the neonate to the young adult rat. Changes to neonatal cardiac and plasma lipid profiles during hypoxia likely allowed for greater metabolic and physiologic flexibility and increased chances for survival. Persistent alterations in the neonatal cardiac lipid profile following recovery from hypoxia may play a role in the development of rhythm disturbances.
新生儿对急性缺氧的生理和生化反应尚未得到充分描述。脂肪酸和脂质在心脏功能的大多数方面发挥着重要作用。
我们进行了全面的脂质谱分析，以调查在缺氧 2 小时后暴露于缺氧环境的新生和幼鼠的心脏组织和血浆中发生的变化，并在缺氧恢复 2 小时后进行检测。
缺氧新生儿的心脏和血浆中的短链酰基肉碱浓度和大多数血浆长链脂肪酸浓度降低。缺氧恢复后，新生鼠心脏中丙酰肉碱、棕榈酰肉碱、硬脂酰肉碱的浓度增加，而新生鼠血浆中油酰肉碱和亚油酸肉碱的浓度增加。缺氧幼鼠心脏和血浆中的长链脂肪酸和长链酰基肉碱浓度增加；这些代谢物在缺氧恢复后恢复到基线值。
从新生儿到幼鼠成熟过程中，急性缺氧对心脏和血浆脂质谱有不同的影响。缺氧期间新生儿心脏和血浆脂质谱的变化可能为代谢和生理灵活性提供了更大的空间，并增加了生存的机会。缺氧恢复后新生儿心脏脂质谱的持续改变可能在心律失常的发展中起作用。
