van der Vusse G J, van Bilsen M, Glatz J F
Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands.
Cardiovasc Res. 2000 Jan 14;45(2):279-93. doi: 10.1016/s0008-6363(99)00263-1.
Fatty acids are important energy donors for the healthy heart. These substrates are supplied to the myocardium bound to albumin to overcome their low solubility in aqueous solutions such as blood plasma. Transport from the microvascular compartment to the mitochondria inside the cardiomyocytes is most likely a combination of passive and protein-mediated diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.
脂肪酸是健康心脏重要的能量供体。这些底物与白蛋白结合后被输送到心肌，以克服它们在诸如血浆等水溶液中溶解度低的问题。从微血管腔室到心肌细胞内线粒体的转运很可能是被动扩散和蛋白质介导扩散的结合。脂肪酸转运蛋白的组织含量改变可能导致心肌疾病，如糖尿病性心肌病、心脏肥大和心力衰竭。
