儿茶酚氧位甲基转移酶 val108/158met 基因型、重性抑郁症及重性抑郁症对选择性 5-羟色胺再摄取抑制剂的反应。
Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder.
机构信息
University of Tampere, Medical School, Tampere, Finland.
出版信息
Psychiatry Res. 2010 Mar 30;176(1):85-7. doi: 10.1016/j.psychres.2009.03.010. Epub 2010 Jan 13.
Abstract
The functional val108/158met polymorphism of the COMT gene (rs4680) was evaluated in major depressive disorder (MDD), and in the treatment response to antidepressants in MDD. We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.
摘要
COMT 基因（rs4680）的功能性 val108/158met 多态性在重度抑郁症（MDD）和 MDD 对抗抑郁药的治疗反应中进行了评估。我们无法证明这种 COMT 单核苷酸多态性（SNP）在对选择性 5-羟色胺再摄取抑制剂的治疗反应或在 MDD 患者和对照受试者之间的分布有任何显著差异。
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