Strömskag K E, Minor B G, Post C
Department of Anesthesiology, Molde County Hospital, Norway.
Reg Anesth. 1991 Jan-Feb;16(1):43-7.
The absorption and distribution of bupivacaine in several tissues was studied after interpleural injection of 14C-labelled bupivacaine through a small needle interpleurally on the right side in male rats. 14C-labelled bupivacaine 10 microCi/mmol was injected at a dose of 2.5 mg/kg. The animals, a total of 42, six at each testing time, were sacrificed at 5, 10, 20, 30, 60, 120 and 180 minutes after the interpleural injection. Bupivacaine concentration was then determined on the basis of the amount of radioactivity in tissues taken from 23 different locations. The highest concentration of bupivacaine, about 40 pmol/micrograms tissue, was found in the right lung in the middle and inferior lobes. In the inferior and dorsal aspects of the right thoracic wall, the concentrations were in the same range. In the more peripheral organs, such as the musculature in the legs, the concentration was as low as less than 5 pmol/micrograms. In the central nervous system, the concentration was less than 10 pmol/micrograms. Our conclusion is that interpleurally administered bupivacaine remains in the area of injection for a considerable time.
通过在雄性大鼠右侧经小针进行胸膜内注射14C标记的布比卡因，研究了布比卡因在几种组织中的吸收和分布情况。以2.5mg/kg的剂量注射10微居里/毫摩尔的14C标记布比卡因。总共42只动物，在胸膜内注射后的5、10、20、30、60、120和180分钟时，每次测试时间点取6只动物进行处死。然后根据从23个不同部位采集的组织中的放射性量来测定布比卡因浓度。在右肺中叶和下叶发现布比卡因的最高浓度，约为40皮摩尔/微克组织。在右胸壁的下部和背侧，浓度处于相同范围。在更外周的器官，如腿部肌肉组织中，浓度低至小于5皮摩尔/微克。在中枢神经系统中，浓度小于10皮摩尔/微克。我们的结论是，胸膜内给药的布比卡因在注射部位停留相当长的时间。
