Tulane University School of Medicine, 1430 Tulane Avenue, SL 48, New Orleans, LA 70112, USA.
Trends Endocrinol Metab. 2010 Apr;21(4):245-54. doi: 10.1016/j.tem.2009.12.005. Epub 2010 Jan 12.
Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion formation but also in lesion progression and destabilization. Although most growth factors are thought to promote vascular smooth muscle cell proliferation and migration, thereby increasing neointima, recent animal studies indicate that insulin-like growth factor (IGF)-1 exerts both pleiotropic anti-oxidant effects and anti-inflammatory effects, which together reduce atherosclerotic burden. This review discusses the effects of IGF-1 in models of vascular injury and atherosclerosis, emphasizing the relationship between oxidative stress and potential atheroprotective actions of IGF-1.
动脉粥样硬化是一种慢性炎症性疾病，其中早期的内皮功能障碍和内膜下修饰的脂蛋白沉积进展为复杂的、晚期的病变，容易发生侵蚀、破裂和血栓形成。氧化应激不仅在初始病变形成中起关键作用，而且在病变进展和不稳定中也起关键作用。尽管大多数生长因子被认为可促进血管平滑肌细胞增殖和迁移，从而增加新生内膜，但最近的动物研究表明，胰岛素样生长因子（IGF）-1 具有多种抗氧化作用和抗炎作用，共同降低动脉粥样硬化负担。本文综述了 IGF-1 在血管损伤和动脉粥样硬化模型中的作用，强调了氧化应激与 IGF-1 的潜在抗动脉粥样硬化作用之间的关系。
