通过操纵翻译后修饰来改变平衡。
Tipping the balance by manipulating post-translational modifications.
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
出版信息
Curr Opin Microbiol. 2010 Feb;13(1):34-40. doi: 10.1016/j.mib.2009.12.004. Epub 2010 Jan 12.
Abstract
Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
摘要
细菌在感染过程中会使用多种机制来确保其生存，包括通过 III 型分泌系统将毒力因子输送到感染细胞中。这些因子表现出多种活性，在许多情况下模仿了宿主用来抵御感染的真核机制。在此，我们描述了一类效应物，它们利用翻译后修饰（有些是可逆的，有些是不可逆的）来操纵宿主信号系统，从而颠覆宿主的反应。
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