老年人经抑制性 rTMS 治疗后运动皮层可塑性降低。
Reduced motor cortex plasticity following inhibitory rTMS in older adults.
机构信息
Discipline of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia.
出版信息
Clin Neurophysiol. 2010 Mar;121(3):441-7. doi: 10.1016/j.clinph.2009.11.089. Epub 2010 Jan 13.
OBJECTIVE
Ageing is accompanied by diminished practice-dependent plasticity. We investigated the effect of age on another plasticity inducing paradigm, repetitive transcranial magnetic stimulation (rTMS).
METHODS
Healthy young (n=15; 25+/-4 years) and old (n=15; 67+/-5 years) adults participated in two experiments. Motor evoked potentials (MEPs) were measured in the target muscle (first dorsal interosseus, FDI) and a remote muscle (abductor digiti minimi) during a set of single stimuli. Subjects then received real or sham inhibitory rTMS (intermittent subthreshold trains of 6Hz stimulation for 10min). MEPs were measured for 30min after rTMS.
RESULTS
In young adults, MEPs in the target FDI muscle were approximately 15% smaller in the real rTMS experiment than in the sham rTMS experiment (P<0.026). In old adults, FDI MEP size did not differ between experiments.
CONCLUSIONS
Advancing age is associated with reduced efficacy of inhibitory rTMS.
SIGNIFICANCE
This work has important implications for the potential therapeutic use of rTMS in stroke and neurological disease.
目的
衰老伴随着实践依赖性可塑性的降低。我们研究了年龄对另一种诱导可塑性的范式——重复经颅磁刺激（rTMS）的影响。
方法
健康的年轻（n=15；25+/-4 岁）和老年（n=15；67+/-5 岁）成年人参加了两项实验。在一组单刺激期间，测量目标肌肉（第一背骨间肌，FDI）和远程肌肉（小指展肌）的运动诱发电位（MEPs）。然后，受试者接受真实或假抑制 rTMS（6Hz 刺激的间歇性亚阈列车，持续 10 分钟）。rTMS 后 30 分钟测量 MEPs。
结果
在年轻成年人中，真实 rTMS 实验中目标 FDI 肌肉的 MEPs 比假 rTMS 实验中大约小 15%（P<0.026）。在老年成年人中，实验之间 FDI MEPs 大小没有差异。
结论
年龄的增长与抑制性 rTMS 的疗效降低有关。
意义
这项工作对 rTMS 在中风和神经疾病中的潜在治疗应用具有重要意义。
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