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对顶叶-运动通路进行重复的间隔配对联想刺激可维持老年人的皮质运动兴奋性。

Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.

作者信息

Goldenkoff Elana R, Deluisi Joseph A, Brissenden James A, Lee Taraz G, Polk Thad A, Taylor Stephan F, Hampstead Benjamin M, Vesia Michael

机构信息

School of Kinesiology, University of Michigan, Ann Arbor, USA.

Department of Psychology, University of Michigan, Ann Arbor, USA.

出版信息

Clin Neurophysiol. 2025 May;173:76-85. doi: 10.1016/j.clinph.2025.03.003. Epub 2025 Mar 8.

Abstract

INTRODUCTION

Cortical paired associative stimulation (cPAS), repeated at spaced intervals and applied to the primary motor cortex (M1) and posterior parietal cortex (PPC), has a dose-dependent effect on corticomotor excitability in young adults. The present study investigated whether aging affects this additive (nonhomeostatic) metaplasticity by performing the same manipulation in a sample of older adults.

METHODS

In the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions. In the single-dose control cPAS condition, one session of the Hebbian-plasticity-induction cPAS protocol was followed by two sessions of a control non-Hebbian cPAS protocol. We measured motor-evoked potentials (MEPs) before and after each cPAS session.

RESULTS

Compared to a single dose of cPAS, the multi-dose cPAS protocol prevented the reduction in MEP amplitude, resulting in relatively greater corticomotor excitability following the Hebbian procedures. We did not find evidence for an increase in MEP amplitude after the repeated, spaced Hebbian-plasticity-induction cPAS protocol from baseline levels, suggesting reduced neuroplasticity in older adults compared to young adults.

CONCLUSION

Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.

SIGNIFICANCE

These findings provide insight into age-related differences in neuroplastic capacity in healthy humans.

摘要

引言

皮层配对联想刺激(cPAS)以一定间隔重复施加于初级运动皮层(M1)和顶叶后皮质(PPC),对年轻成年人的皮质运动兴奋性具有剂量依赖性效应。本研究通过对一组老年人进行相同操作,探讨衰老是否会影响这种累加性(非稳态)的可塑性变化。

方法

在多剂量cPAS条件下,连续进行三个阶段的赫布可塑性诱导cPAS方案,各阶段之间间隔50分钟。在单剂量对照cPAS条件下,先进行一个阶段的赫布可塑性诱导cPAS方案,随后进行两个阶段的对照非赫布cPAS方案。我们在每个cPAS阶段前后测量运动诱发电位(MEP)。

结果

与单剂量cPAS相比,多剂量cPAS方案可防止MEP波幅降低,在赫布程序后产生相对较高的皮质运动兴奋性。我们没有发现重复、间隔的赫布可塑性诱导cPAS方案后MEP波幅相对于基线水平增加的证据,这表明与年轻成年人相比,老年人的神经可塑性降低。

结论

对顶叶 - 运动通路进行重复间隔的配对联想刺激可维持老年人的皮质运动兴奋性。

意义

这些发现为健康人群中与年龄相关的神经可塑性能力差异提供了见解。

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