Mackenzie R A, Skuse N F, Lethlean A K
J Neurol Sci. 1977 Nov;34(2):175-89. doi: 10.1016/0022-510x(77)90066-1.
Surface, needle and micro-electrode recordings were obtained from sensory nerves of patients with various types of peripheral neuropathy. Changes in amplitude and conduction velocity of nerve action potentials were measured after a single conditioning stimulus and after tetanic stimulation for 2 min. In patients with hereditary forms of axonal degeneration (AD), recovery processes of nerve fibres of all conduction velocities were normal; in acquired forms of AD fibres with conduction velocity less than 30 m/sec had greater and more prolonged post-tetanic depression than control nerves of similar conduction velocity. Where neuropathy was associated with segmental demyelination (SD), fibres of all conduction velocities had prolonged recovery processes after both single and tetanic stimulation. The changes were especially marked at higher skin temperature, and were greater than the changes seen in nerves with acquired forms of AD. Finally, 2 sural nerves were studied during the process of Wallerian degeneration after a biopsy had been obtained proximally, and recovery processes did not change during the period of degeneration. Perceptual abnormalities were similar in AD and SD. It is suggested that changes in recovery processes of nerve fibres with segmental demyelination or regeneration after injury contribute to the perceptual abnormalities which occur in clinically encountered peripheral neuropathies.
从患有各种类型周围神经病变的患者的感觉神经获取了表面、针电极和微电极记录。在单次条件刺激后以及强直刺激2分钟后，测量了神经动作电位的幅度和传导速度的变化。在遗传性轴索性变性（AD）患者中，所有传导速度的神经纤维的恢复过程均正常；在获得性AD中，传导速度小于30米/秒的纤维比传导速度相似的对照神经具有更大且更持久的强直后抑制。在神经病变与节段性脱髓鞘（SD）相关的情况下，所有传导速度的纤维在单次和强直刺激后恢复过程均延长。这些变化在较高皮肤温度下尤为明显，且大于在获得性AD神经中观察到的变化。最后，在近端获取活检后，对2条腓肠神经在华勒氏变性过程中进行了研究，在变性期间恢复过程未发生变化。AD和SD中的感觉异常相似。有人提出，节段性脱髓鞘或损伤后再生的神经纤维恢复过程的变化导致了临床遇到的周围神经病变中出现的感觉异常。
