Smith K J, Hall S M
J Neurol Sci. 1980 Nov;48(2):201-19. doi: 10.1016/0022-510x(80)90201-4.
The changes in the conduction properties of peripheral nerve fibres of the mouse were examined during the phases of segmental demyelination, and remyelination, following the intraneural injection of lysophosphatidyl choline (LPC). In this lesion the sequence of the morphological changes was well synchronised in the different calibre fibres and this permitted a closer correlation to be made between the histological and physiological events than has been possible with other experimental models. Conduction in the nerve fibres was blocked during demyelination and for 1--2 days after the axons were completely free of myelin. In many fibres, however, conduction was later restored at about the time the demyelinated axon membrane became reassociated with debris-free Schwann cells, but prior to remyelination; at this time the fibres were unable to conduct closely spaced impulses and the conduction velocity was low. During the subsequent period of remyelination the ability of the fibres to conduct closely spaced impulses was fully restored and the conduction velocity progressively increased; the remyelinated internodes remained both thinner and shorter than normal. The physiological properties of the fibres were described in terms of their refractory periods of transmission (RPTs) as well as their conduction velocities; only the description in terms of the RPT correlated well with the histological events and with the degree of the behavioural deficit.
在神经内注射溶血磷脂酰胆碱（LPC）后，对小鼠外周神经纤维在节段性脱髓鞘和再髓鞘化阶段的传导特性变化进行了研究。在这种损伤中，不同直径纤维的形态学变化序列高度同步，这使得与其他实验模型相比，能够在组织学和生理学事件之间建立更紧密的关联。在脱髓鞘期间以及轴突完全无髓鞘后的1至2天内，神经纤维的传导被阻断。然而，在许多纤维中，传导在脱髓鞘轴突膜与无碎片的施万细胞重新结合时恢复，但在再髓鞘化之前；此时，纤维无法传导紧密间隔的冲动，传导速度较低。在随后的再髓鞘化期间，纤维传导紧密间隔冲动的能力完全恢复，传导速度逐渐增加；再髓鞘化的节间段仍然比正常的更细、更短。根据纤维的传递不应期（RPT）以及传导速度来描述其生理特性；只有根据RPT的描述与组织学事件以及行为缺陷程度有很好的相关性。
